Tourism revival process in Nepal might be disrupted in the upcoming autumn with a gradual resurgence of COVID-19 infections in many parts of the nation. The reappearance of the pandemic is mainly attributed to the new sub-variants, including BA.5, of the Omicron variant. This sub-variant has been found to be more contagious than its previous lineages. Some cases driven by it have lately been detected in Nepal and many other countries around the world. The steady rise in the number of infections in the nation can be taken as a clear indication of the emergence of the fourth COVID wave.